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Search Results for " retinoid receptor "

26

抑制剂 & 化合物

1

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Cat. No.	Product Name	Target	Signaling Pathways
T3955	AR7	Retinoid Receptor	Metabolism
	AR7 是一种非典型的 RARA/RARα(视黄酸受体 α) 拮抗剂，能够特异性激活伴侣介导的自噬活性，对自噬无影响。
T7894	Tazarotenic acid 6-[2-(3,4-二氢-4,4-二甲基-2H-1-苯并噻喃-6-基)乙炔基]-3-吡啶甲酸,AGN-190299	Others	Others
	Tazarotenic acid (AGN-190299) 是 Tazarotene 的代谢物。它与视黄酸受体 (RAR) 的结合位点是类视黄醇作用的可能的分子靶点。它对疣状角化不良具有潜在的研究价值。
T14912	CD3254	Retinoid Receptor	Metabolism
	CD3254 是一种具有选择性和强效性的类视黄醇 X 受体 (RXR) 激动剂，可抑制伴有OGD/再氧合的神经元细胞死亡。
T7388	GSK805	ROR	Metabolism
	GSK805 是能够生物利用的、具有 CNS 穿透性的 RORγt 抑制剂。
T23383	SR11237 SR 11237	Others; RAR/RXR	Metabolism; Others
	SR11237 是一种泛视黄醇 X 受体 (RXR) 激动剂。 SR11237 导致 RXR/RXR 同源二聚体形成并反式激活包含 RXR 反应元件的报告基因。
T17209	UVI 3003	Retinoid Receptor; Autophagy	Autophagy; Metabolism
	UVI 3003 是一种高度选择性的类视黄醇 X 受体拮抗剂。在 Cos7 细胞中，它抑制非洲爪蟾蜍和人RXRα的活性，IC50值分别为 0.22 和 0.24 μM。
T9635	Cedirogant ABBV-157	ROR	Metabolism
	Cedirogant (ABBV-157) 是一种口服有活性的 RORγt 反向激动剂，可用于研究银屑病。
T11844	LG-100064 4-[(5,6,7,8-四氢-3,5,5,8,8-五甲基-2-萘基)羰基]苯甲酸	Retinoid Receptor; Autophagy	Autophagy; Metabolism
	LG-100064 是一种类视黄醇 X 受体激动剂，对 RXRα、RXRβ 和 RXRγ 的 EC50值分别为 330、200 和 260 nM，可用于癌症研究。
T11303	Fluorobexarotene	Retinoid Receptor	Metabolism
	Fluorobexarotene 是一种有效的类视黄醇 X 受体 (RXR) 激动剂。Fluorobexarotene 对 RXRα 受体的 Ki 值为 12 nM，EC50 值为 43 nM。Fluorobexarotene 具有明显的 RXR 结合亲和力，比 Bexarotene 高75%。
T22843	HX 531	Retinoid Receptor	Metabolism
	HX 531 是的RXR 拮抗剂 (IC50:18 nM) 。它能减少高脂饮食小鼠的骨骼肌、白色脂肪组织和肝脏中的甘油三酯含量。
TP1313L	Cecropin B acetate Cecropin B acetate(80451-05-4 Free base)	P450; Retinoid Receptor; Parasite	Metabolism; Microbiology/Virology
	Cecropin B acetate 通过破坏 PXR/类视黄醇 X 受体 α (RXR-α) 复合物与 DNA 序列的结合来诱导 NF-κB 活化并抑制 CYP3A29。 Cecropin B acetate 具有很强的抗菌活性。
T77499	MSU-42011	NOS; Retinoid Receptor; NO Synthase; PERK; Lipid	Apoptosis; Immunology/Inflammation; Metabolism
	MSU-42011 是一种具有口服活性的类视黄醇 X 受体 (RXR) 激动剂。MSU-42011 有效抑制iNOS，低SREBP 诱导和激活RXR 以及 p-ERK 蛋白水平的表达。MSU-42011在kras 驱动的肺癌小鼠模型中表现出抗肿瘤活性。MSU-42011可有效治疗临床前Krasdriven 肺癌且具有免疫调节活性。
T23665	AGN 191701 AGN-191701,AGN191701
	AGN 191701 is an agonist of the Retinoid X receptor.
T69695	Izumerogant
	Izumerogant is an inverse agonist of the retinoid-related orphan receptor-gamma (RORγ).
T24727	ROR Modulator I ROR-Modulator-I,RORModulatorI
	ROR Modulator I is the first potent inverse agonist of the retinoid-related orphan receptor. It also has dual selectivity for RORβ and RORγt.
T70976	AGN-190121
	AGN-190121 is a retinoic acid receptor (RAR) agonist. RAR and Retinoid X Receptor (RXR) ligands can act synergistically to induce hypertriglyceridemia through distinct mechanisms of action.
T19703	LG100268 LG 100268,LG-100268
	LG100268 is an effective and selective rexinoid and retinoid-X receptor agonist. LG100268 binds to the α, β, and γ RXR receptors (IC50 = 3-4 nM).
T25472	GW0791 GW 0791,GW-0791
	GW0791 is a retinoid X receptor α (RXRα) agonist.
T29720	Agn 190727 Agn-190727,Agn190727
	Agn 190727 is a retonoic acid receptor that can induce retinoid-induced hypertriglyceridemia.
T10246	Adapalene sodium salt CD 271 sodium salt,阿达帕林钠	Others	Others
	Adapalene (CD 271; Differin) sodium salt is a synthetic retinoid and a Retinoic acid receptor agonist.
T24857	TBTC
	TBTC is a selective agonist of retinoid X receptor α that acts by improving behavioral deficit in Alzheimer's disease model mice.
T70440	AGN-191659
	AGN-191659 is a Retinoid X Receptor (RXR) pan-agonist. RXR pan-agonists have been shown to modulate endothelial cell proliferation.
T63415	RXR antagonist 1
	RXR antagonist 1 是类视黄醇 X 受体 (Retinoid X Receptor (RXR)) 调节剂，表现出较高的 RXR 拮抗作用 (pA2: 8.06)。RXR antagonist 1 能够用于研究 2 型糖尿病。
T69921	BRF110
	BRF110 is a brain penetrant, potent and selective agonist of nuclear receptor-related 1 (Nurr1):Retinoid X receptor α (RXRα) heterodimer. BRF110 is a neuroprotective agent that prevents dopaminergic neuron demise and striatal dopaminergic denervation in vivo against PD-causing toxins. It induced dopamine biosynthesis in vivo. BRF110 chronic dosing does not induce dyskinesia in mice model.
T37414	CAY10771
	CAY10771 is a dual agonist of farnesoid X receptor (FXR) and peroxisome proliferator-activated receptor δ (PPARδ).1It activates FXR and PPARδ in reporter assays using HEK293T cells (EC50s = 0.94 and 1.5 μM, respectively) and is selective for these receptors over retinoic acid receptor α (RARα), retinoid X receptor α (RXRα), PPARα, PPARγ, and liver X receptor α (LXRα) at 10 μM. 1.Schierle, S., Neumann, S., Heitel, P., et al.Design and structural optimization of dual FXR/PPARδ activatorsJ. Med. Ch...
T35800	MD001
	MD001 is a dual agonist of peroxisome proliferator-activated receptor α (PPARα) and PPARγ.1 It binds to PPARα and PPARγ (Kds = 9.55 and 0.14 μM, respectively) but does not bind to PPARβ/δ at concentrations up to 500 μM. It increases transcriptional activity of PPARα and PPARγ in a cell-based luciferase reporter assay when used at a concentration of 10 μM. MD001 (10 μM) increases expression of PPARα, PPARγ, and retinoid X receptor (RXR), as well as PPARα and PPARγ target genes, in HepG2 cells. It...

化合物

Cat.No: T3955

Target: Retinoid Receptor

Tazarotenic acid

Cat.No: T7894

Synonym: 6-[2-(3,4-二氢-4,4-二甲基-2H-1-苯并噻喃-6-基)乙炔基]-3-吡啶甲酸,AGN-190299

Target: Others

Cat.No: T14912

Target: Retinoid Receptor

Cat.No: T7388

Target: ROR

Cat.No: T23383

Synonym: SR 11237

Target: Others, RAR/RXR

Cat.No: T17209

Target: Retinoid Receptor, Autophagy

Cat.No: T9635

Synonym: ABBV-157

Target: ROR

Cat.No: T11844

Synonym: 4-[(5,6,7,8-四氢-3,5,5,8,8-五甲基-2-萘基)羰基]苯甲酸

Target: Retinoid Receptor, Autophagy

Fluorobexarotene

Cat.No: T11303

Target: Retinoid Receptor

Cat.No: T22843

Target: Retinoid Receptor

Cecropin B acetate

Cat.No: TP1313L

Synonym: Cecropin B acetate(80451-05-4 Free base)

Target: P450, Retinoid Receptor, Parasite

Cat.No: T77499

Target: NOS, Retinoid Receptor, NO Synthase, PERK, Lipid

Cat.No: T23665

Synonym: AGN-191701,AGN191701

Cat.No: T69695

ROR Modulator I

Cat.No: T24727

Synonym: ROR-Modulator-I,RORModulatorI

Cat.No: T70976

Cat.No: T19703

Synonym: LG 100268,LG-100268

Cat.No: T25472

Synonym: GW 0791,GW-0791

Cat.No: T29720

Synonym: Agn-190727,Agn190727

Adapalene sodium salt

Cat.No: T10246

Synonym: CD 271 sodium salt,阿达帕林钠

Target: Others

Cat.No: T24857

Cat.No: T70440

RXR antagonist 1

Cat.No: T63415

Cat.No: T69921

Cat.No: T37414

Cat.No: T35800

Cat. No.	Product Name	Target	Signaling Pathways
TN6735	Bigelovin	Apoptosis; Reactive Oxygen Species; Retinoid Receptor; Autophagy; RAR/RXR	Apoptosis; Autophagy; Immunology/Inflammation; Metabolism; NF-κB
	Bigelovin 是从海百合中分离得到的一种倍半萜内酯，是选择性视黄素 X 受体 α 激动剂。它通过抑制ROS 的生成来调节 mTOR 信号通路。它诱导凋亡和自噬，有抗肿瘤活性。

天然产物

Cat.No: TN6735

Target: Apoptosis, Reactive Oxygen Species, Retinoid Receptor, Autophagy, RAR/RXR

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